Buy Simplicef (100mg tablets, 100ct) Online, rx medicine for dogs

Simplicef (100mg tablets, 100ct) (Rx)

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Product Description

Antibiotics for dogs are an effective way to keep your pet safe from different health problems.

Now with Simplicef (100mg tablets, 100ct), you can treat a variety of skin infection in dogs as well as ear, urinary tract issues, respiratory, and bone infections. This antibiotic for pet can effectively kill bacteria, fungi, and protozoa.

Simplicef 100 mg, 100 Tablets is an antibiotic for dogs with the main ingredient cefpodoxime proxetil that effectively treats a variety of dog skin problems, ear, urinary tract issues, respiratory tract, and bone infections.

Simplicef tablets belong to the cephalosporin class of antibiotic medicine. It is manufactured for Pharmacia & Upjohn Company, Division of Pfizer Inc., New York.

Please note: This is a special order pet med item that may require 10-14 days lead time before it is available for shipping.

Now you can order dog medications and antibiotic for pets online and get the pet medicine delivered right at your doorstep. At our pet drug online pharmacy based in Texas, you can get high quality discount pet meds as well as dog medicine.


Oral Use In Dogs Only


Federal (USA) law restricts this pet medicine to use by or on the order of a licensed veterinarian.


Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic cephalosporin antibiotic.

Cefpodoxime proxetil is a prodrug; its active metabolite is cefpodoxime. All doses of SIMPLICEF (cefpodoxime proxetil) antibiotics for dogs are expressed in terms of the active cefpodoxime moiety.

SIMPLICEF Tablets is available as:

100 mg, each reddish-orange, elliptical, scored tablet contains cefpodoxime proxetil equivalent to 100 mg of cefpodoxime.

200 mg, each light orange, round rectangle, scored tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime.


SIMPLICEF antibiotics for dogs are indicated for the treatment of skin infections in dogs caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus,

Streptococcus canis (group G, β hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.


Dose range:  The dose range of SIMPLICEF (cefpodoxime proxetil) pet medicine is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food.

The determination of dosage of these dog antibiotics for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient’s host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.


SIMPLICEF dog antibiotics should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections with this antibiotic for pets should not be continued for more than 3-4 days if no response to therapy is seen.

Dosing Charts:

For daily oral administration of SIMPLICEF pet med at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).

Table 1. Dose Table for SIMPLICEF Tablets at 5 mg/kg Total Daily Dosage

Weight of Dog (lbs)
Daily Dose22446688132
No. of 100 mg tablets0.511.51
No. of 200 mg tablets11
Weight of Dog (kgs)
Daily Dose1020304060
No. of 100 mg tablets0.511.51
No. of 200 mg tablets11

Table 2. Dose Table for SIMPLICEF Tablets at 10 mg/kg Total Daily Dosage

Weight of Dog (lbs)
Daily Dose1122446688132
No. of 100 mg tablets 0.51  1
No. of 200 mg tablets 1123
Weight of Dog (kgs)
Daily Dose51020304060
No. of 100 mg tablets0.51 1
No. of 200 mg tablets 1123


Cefpodoxime proxetil is contraindicated in dogs with known allergy to cefpodoxime or to the β-lactam (penicillins and cephalosporins) group of antibiotics.


This antibiotic for pets is not for human use. Keep this and all dog medications out of reach of children.

Antimicrobial drugs, including penicillin and cephalosporin, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.


The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporin, cefpodoxime proxetil may occasionally induce a positive direct Coombs’ test.


A total of 216 dogs of various breeds and ages ranging from 2 months to 15 years were included in the field study safety analysis. The following table shows the number of dogs displaying each clinical observation.

Table 3. Abnormal Health Findings in the U.S. Field Study

Clinical ObservationSIMPLICEF (n=118)Active Control  (n=98)
Increased water drinking02
Decreased appetite11

Dogs may have experienced more than one of the observations during the study.

To report a suspected adverse reaction after the use of this pet med, call 1-800-366-5288.


Store these antibiotic tablets for dogs at controlled room temperature 20° to 25°C (68° to 77°F). Replace cap securely after each opening.


SIMPLICEF tablets are available in the following strengths (cefpodoxime equivalent), colors, and sizes:

SIMPLICEG 100 mg (reddish-orange, elliptical, scored, debossed with 5228)

Bottles of 100

Bottles of 250

SIMPLICEF 200 mg (light orange, round rectangle, scored, debossed with 5229)

Bottles of 100

Bottles of 250

Distributed by: Pharmacia & Upjohn Company, Division of Pfizer Inc, New York, NY 10017

Additional Information

Bottle Size

100mg tablets, 100ct, 200mg tablets, 100ct

Product Type

Nutrition Medicine, OTC Medicine, Rx Medicine


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