Buy NexGard Online, rx medicine for dogs

NexGard (Rx)

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Product Description

NexGard for Dogs 10.1 – 24 lbs, 3 month supply is a once-monthly flea and tick preventative medicine. NexGard is a beef-flavored soft chew that protects your dog from fleas and ticks for 30 days. From the same manufacturer that brought you Frontline Plus, NexGard dog medicine is dispensed with the package inserts and instructions but does not include the box.

Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5- [3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifl uoroethyl)amino]ethyl.

NEXGARD™ (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Each NexGard chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg).

Order this dog flea medicine and other veterinary medicines and prescription drugs for pets from our Texas based pet pharmacy online shop. We care for your pets!

For

Dogs

Benefits:

  • Contains afoxolaner which kill fleas by over-stimulating their nervous system
  • NexGard pet med kills 100% of fleas within 24 hours
  • NexGard is safe and effective used with any breed of dog

CAUTION:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Indications:

NEXGARD kills adult fleas and is indicated for the treatment and prevention of flea infestations in dogs, and the treatment and control of American Dog tick infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month.

Dosage and Administration:

NEXGARD is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg).

Dosing Schedule:

Body WeightAfoxolaner Per Chewables (mgChewable  Administered
4.0 to 10.0 lbs.11.3One
10.1 to 24.0 lbs.28.3One
24.1 to 60.0 lbs.68One
60.1 to 121.0 lbs.136One
Over 121.0 lbs.Administer the appropriate combination of chewables

 

 NEXGARD can be administered with or without food.  Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. If a dose is missed, administer this dog flea medicine and resume a monthly dosing schedule.

Flea Treatment and Prevention:

Treatment with NEXGARD may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with this dog flea control medicine should continue the entire year without interruption.

To minimize the likelihood of fl ea reinfestation, it is important to treat all animals within a household with an approved fl ea control product.

Tick Treatment and Control:

Treatment with NEXGARD may begin at any time of the year (see Effectiveness).

Contraindications:

There are no known contraindications for the use of NEXGARD for dogs.

Warnings:

This dog flea medicine is not for use in humans. Keep this and all dog medicines out of the reach of children. In case of accidental ingestion, contact a physician immediately.

Precautions:

The safe use of NEXGARD for dogs in breeding, pregnant or lactating dogs has not been evaluated.

Use with caution in dogs with a history of seizures (see Adverse Reactions).

Adverse Reactions:

In a well-controlled US fi eld study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NEXGARD pet med.

Over the 90-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. The most frequently reported adverse reaction with this pet med was vomiting. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the fi rst dose but not subsequent doses.

Table 1: Dogs With Adverse Reactions.

Treatment Group
AfoxolanerOral active control
N1% (n=415)N2%   (n=200)
Vomiting (with and without blood)174.12512.5
Dry/Flaky     Skin133.121.0
Diarrhea (with and without blood)133.173.5
Lethargy71.742.0
Anorexia51.2 94.5

1 Number of dogs in the afoxolaner treatment group with the identified abnormality.

2 Number of dogs in the control group with the identified abnormality.

In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose of this dog flea medicine and on the same day after receiving the second dose of NEXGARD pet med. This dog experienced a third seizure one week after receiving the third dose. The dog remained enrolled and completed the study. Another dog with a history of seizures had a seizure 19 days after the third dose of NEXGARD. The dog remained enrolled and completed the study. A third dog with a history of seizures received NEXGARD and experienced no seizures throughout the study.

To report suspected adverse events, for technical assistance or to obtain a copy of the MSDS, contact Merial at 1-888-637-4251 or www.merial.com/nexgard. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation.

Mode of Action:

Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines in dogs. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors.

Effectiveness:

In a well-controlled laboratory study, NEXGARD dog flea medicine demonstrated 100% effectiveness against adult fleas 24 hours post-infestation for 35 days, and was ≥ 93% effective at 12 hours post-infestation through Day 21, and on Day 35.  On Day 28, NEXGARD was 81.1% effective 12 hours post-infestation.  Dogs in both the treated and control groups that were infested with fleas on Day -1 generated fl ea eggs at 12- and 24-hours post-treatment (0-11 eggs and 1-17 eggs in the NEXGARD treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12- and 24-hours, respectively). At subsequent evaluations post-infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs). In a 90-day US field study conducted in households with existing fl ea infestations of varying severity, the effectiveness of NEXGARD against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively.

Collectively, the data from the two studies (one laboratory and one field) demonstrate that NEXGARD kills fleas before they can lay eggs, thus preventing subsequent flea infestations after the start of treatment of existing flea infestations in dogs.

In well-controlled laboratory studies, NEXGARD for dogs demonstrated >97% effectiveness against Dermacentor variabilis 48 hours post-infestation for 30 days.

Animal Safety:

In a margin of safety study, NEXGARD chewables was administered orally to 8- to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. Dogs in the control group were sham-dosed. There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. Vomiting occurred throughout the study, with a similar incidence in the treated and control groups, including one dog in the 5x group that vomited four hours after treatment with this dog flea medicine.

In a well-controlled field study, NEXGARD dog flea medicine was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, NSAIDS, anesthetics, and antihistamines. No adverse reactions were observed from the concomitant use of NEXGARD chewables with other medications.

Storage Information:

Store this dog flea control medicine at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).

How Supplied:

NEXGARD for dogs is available in four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner. Each chewable size is available in color-coded packages of 3 or 6 beef-flavored chewables.

NADA 141-406, Approved by FDA

Marketed by: Frontline Vet Labs™, a Division of Merial Limited. Duluth, GA 30096-4640 USA

Made in Brazil.

1050-4493-00

Rev. 7/2013

™NEXGARD and FRONTLINE VET LABS are trademarks of Merial.

©2014 Merial. All rights reserved.

Additional Information

Bottle Size

Dog 10.1 to 24 lbs – 3pk, Dog 10.1 to 24 lbs – 6pk, Dog 24.1- 60 lbs – 3pk, Dog 24.1- 60 lbs – 6pk, Dogs 4 – 10 lbs – 3pk, Dogs 4 – 10 lbs – 6pk, Dogs 60.1 – 121 lbs – 3pk, Dogs 60.1 – 121 lbs – 6pk

Color

Blue, Orange, Purple, Red

Product Type

Nutrition Medicine, OTC Medicine, Rx Medicine

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