K-Brovet POTASSIUM BROMIDE (500MG 60CT) is a Seizure Medications for Dogs.
K-BroVet 500 mg is an anticonvulsant medication for controlling seizures in dogs. It is available in a highly palatable chewable tablet or oral liquid solution form. K-BroVet pet meds may be used alone or in conjunction with other treatments.
K-BroVet 500 mg, 60 Chewable Tablets is a potassium bromide medication used to treat seizure disorders like epilepsy in dogs. K-BroVet can be used alone or with other anticonvulsants.
K-BROVET ™ Oral Solution is a butterscotch vanilla flavored solution containing 250 mg/mL of potassium bromide, cyanocobalamin and pyridoxine HCl.
K-BROVET™ Chewable Tablets for dogs are liver flavored tablets containing 250 mg or 500 mg of potassium bromide and cyanocobalamin.
This dog seizure medicine is by PRN Pharmacal.
Order K-BROVET 500 mg and other dog meds and pet medications from our pet pharmacy online based in Texas.
- Potassium bromide tablets for dogs
- Safe for use with most other seizure treatments prescribed by your veterinarian
Federal law restricts this pet meds to use by or on the order of a licensed veterinarian.
Oral Solution 10 FL OZ (300mL)
500mg Tablet (60ct) bottle
250mg Tablet (60ct) bottle
Store this dog meds in a tightly sealed container at room temperature (59-86°F).
Keep pet medications out of reach of children and animals.
Manufactured For PRN PHARMACAL,
An Employee-Owned Company, PENSACOLA, FL 32514
K-BROVET™ potassium bromide is used to treat seizure in dogs. It can be used in addition to therapy with other agents or as the sole anticonvulsant.
K-BROVET™ should not be used in animals with a history of hypersensitivity to Bromide or any of the components of the solution or tablets.
DOSAGE AND ADMINISTRATION
Recommended Dosage for K-BROVET™ Oral Solution and Tablets:
To achieve a serum level of approximately 1 mg/mL, give 120 mg/kg PO daily for 5 days then reduce to 30 mg/kg PO once daily. To achieve a serum level of approximately 1.5 mg/mL, give 160 mg/kg PO for 5 daysand then reduce to 40 mg/kg PO once daily thereafter.
Among dogs responses to bromide may vary, treatment should be tailored to the individual dog, based on serum bromide concentration, success of seizure control, and the observation of adverse effects. Steady state serum concentrations generally take 4 to 5 months in dogs; therapeutic concentrations may be reached before steady state at about 4 weeks after the beginning of treatment, serum bromide concentration may be tested to assess the response to product and, if results are satisfactory, the next testing for steady state serum levels is typically about 4 months. If the dog’s serum concentration is within range and the dog is doing well in the therapeutic range, serum concentration may then be tested every 6 to 12 months. Serum bromide is typically evaluated at the end of the loading period, then as described above when an animal is started with a loading dose.
– An oral dose of 30 mg of Bromide per kg of body weight every twelve hours for 115 days produced a steady state serum concentration of 2.45 mg/mL (range, 1.78 to 2.69 mg/mL) in Beagles fed a diet containing 0.55% chloride.
This dog meds to treat seizures in dogs should be used cautiously in older animals as they will be more susceptible to adverse effects.
This pet medication is not indicated for use in cats.
Possible Side Effects:
Dog may experience drowsiness when taking these seizure medications for dogs but this will generally go away after approximately 3 weeks. Increased hunger, thirst, urination, vomiting, constipation, anorexia, and uncoordinated movements may occur with K-BROVET™. During the load in dose increased nausea may be experienced.
There is no information on the relative frequency of pancreatitis in dogs associated with bromide therapy alone.
However, pancreatitis has been reported to be more frequent in dogs on concurrent phenobarbital and bromide therapy than dogs on phenobarbital alone.
Personality changes have been occasionally reported in dogs on bromide, including attention seeking, irritability or aggression, and aimless pacing.
The effects of bromide on canine reproduction have not been studied.
Safety of administering bromide to neonates and young animals has not been evaluated.
Drug interactions and/or related effects
Drug interactions and/or related effects have been selected on the basis of their clinical significance (possible mechanism in parentheses where appropriate) – not necessarily inclusive (»=major clinical significance):
Note: Any of the following pet medications taken in combinations, depending on the amount taken, could also interact with K-BROVET™. Medications and foods containing chloride, bromide and chloride compete for reabsorption by the kidneys; increased amounts of chloride can promote loss of bromide in the urine, leading to a lowering of serum bromide concentrations: Decreased chloride consumption will promote increased renal reabsorption of bromide
Halothane anesthesia (when inhaled a percentage of halothane is metabolized by dogs to produce bromide, along with other compounds; peak serum concentration occurs within about a day and, in one group of dogs, ranged from 0.04 to 0.088 mg/mL and persisted, with some diminishment, for at least ten days.
Consideration should be given to animals that must have repeated anesthesia or that already require high serum bromide concentration for seizure control. Increased bromide levels due to metabolism of halothane are unlikely to be a significant risk for bromide toxicity in most dogs.
Mechanism of action/Effect:
Bromide’s mechanism of action of has not been clearly defined. By preferential movement across neuronal membranes via gamma-amino butyric (GABA) – activated chloride channels, bromide may aid in controllingseizures through hyperpolarization of neuronal cell membranes, leading to stabilization and decreased sensitivity to epileptic foci.
Volume of distribution – Dogs: 0.45 ± 0.07 L/kg
Protein binding: Bromide is minimally protein bound.
Biotransformation: Bromide is not biotransformed by the liver and is eliminated unchanged, primarily by renal clearance.
Half-life: Elimination –
Bromide is freely filtered by the glomerulus, but is reabsorbed by the kidneys, in competition with chloride.
Bromide reabsorption will predominate in the absence of a large chloride load, causing a significantly extended elimination half-life in dogs.
Increasing chloride intake by an animal on a low chloride diet will decrease the half-life of elimination.
Renal. Because bromide is widely distributed, minute amounts will also be excreted in saliva, sweat and feces.
Rate of elimination of bromide will increase in dogs that receive a high level of chloride supplementation.
For more information in cases of overdose or unintentional ingestion, contact the American Society for the Prevention of Cruelty to Animals (ASPCA) National Animal Poison Control Center (888-426-4435 or 900-443-0000; a fee may be required for consultation) and/or the drug manufacturer.
Note: Signs of bromide toxicity in dogs are dose-related but dogs differ in their sensitivity. Bromide toxicity in dogs has rarely been reported in dogs with serum bromide concentrations of less than 1.5 mg/mL. Signs have been reported in some dogs with relatively low serum concentration (2.75 mg/mL) while not appearing in other dogs with significantly higher concentration (4 mg/mL).
Dogs on concurrent bromide and phenobarbital therapy may be prone to bromide toxicity at lower serum concentrations than when bromide is administered alone.
Other physical factors may also play a role in sensitivity.
Short-term bromide toxicity in dogs is considered completely reversible.
However, mild bromide toxicity in dogs can progress to more severe nervous system dysfunction with ongoing high serum concentration of bromide.
Other species – Bromide toxicity has also been reported in cattle, goats and horses fed hay that contained bromide ion residue from accidental treatment with methyl bromide. Signs included ataxia, hind limb weakness, joint swelling, and sedation or recumbency.
Clinical effects of overdose
Clinical signs may appear with serum bromide concentration >1.5 mg/mL in dogs on bromide therapy alone, but become more common as serum concentration increases, and most common when serum concentration exceeds 4 mg/mL in dogs receiving bromide as the only anticonvulsant (2 to 3 mg/mL in dogs receiving concurrent phenobarbital and bromide).
Ataxia; diarrhea; hematochezia; salivation, excessive; shivering; skin lesions; stupor, progressing to coma and death – Reported with a dose of 200 to 500 mg/kg a day for 4 to 26 weeks.
Treatment of bromide toxicity in dogs
Recommended treatment consists of the following:
For dogs on concurrent phenobarbital and bromide therapy with mild sedation, ataxia or hind limb weakness, a 10 to 25% reduction in phenobarbital may resolve the signs within five to seven days.
– For dogs receiving bromide as the only anticonvulsant, K-BROVET pet med may be discontinued for a few days while monitoring serum concentration, to see if mild signs of toxicity will resolve.
If necessary, renal excretion of bromide may be accelerated by increasing sodium chloride consumption or administering 0.9% sodium chloride intravenously over twelve hours, depending on the severity of the toxicity.
– Supportive treatment
– Continue to monitor