Heartgard Plus for Dogs (Dogs 26-50lbs (green) – 6 Pack) is a canine heartworm disease prevention medicine. It is one of the medicines for dogs to control heartworm disease in dogs.
This pet med also treats ascarids in dogs and hookworms in dogs.
This dog medication by Merial Limited protects your pet from potentially fatal heartworm disease in dogs.
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Dogs weighing between 26-50-lbs
- Prevents infection by heartworms and heartworm disease in dogs
- Kills heartworm larvae in the tissue stage
- Controls hookworm in dogs as well as roundworm infestations
- Comes in chewable form for easy administration
Federal (U.S.A.) law restricts this pet med to use by or on the order of a licensed veterinarian.
For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids in dogs and hookworms in dogs.
HEARTGARD® Plus for dogs should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids in dogs and hookworms in dogs is as follows:
|Dog Weight||Chewables Per Month||Ivermectin Content||Pyrantel Content||Color Coding on Foil Backing and Carton|
|Up to 25 lb||1||68 mcg||57 mg||Blue|
|26 to 50 lb||1||136 mcg||114 mg||Green|
|51 to 100 lb||1||272 mcg||227 mg||Brown|
HEARTGARD meds is recommended for dogs 6 weeks of age and older.
For dogs over 100 lb use the appropriate combination of these chewables.
Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus for dogs palatable, the product can be offered to the dog by hand. Alternatively, this pet med may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.
Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the doses has been lost, redosing is recommended.
HEARTGARD Plus Chewables to treat canine heartworm disease should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD meds must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus for dogs and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Monthly treatment with HEARTGARD meds also provides effective treatment and control of ascarids in dogs and hookworms in dogs. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
HEARTGARD Plus (ivermectin/pyrantel) Chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. HEARTGARD Plus Chewables are also effective against ascarids in dogs and hookworms in dogs.
In acceptability and field trials, HEARTGARD meds was shown to be an acceptable oral dosage form that was consumed at first offering by the majority of dogs.
All dogs should be tested for existing heartworm disease in dogs before starting treatment with HEARTGARD Plus for dogs which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus Chewables.
While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus for dogs is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children.
In case of ingestion of this pet med by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store between 68°F – 77°F (20° – 25°C). Excursions between 59°F – 86°F (15° – 30°C) are permitted. Protect product from light.
In clinical field trials with HEARTGARD Plus for dogs, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of this dog medication: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
HEARTGARD Plus Chewables has been shown to be bioequivalent to HEARTGARD, with respect to the bioavailability of ivermectin. The dose regimens of HEARTGARD Plus for dogs and HEARTGARD are the same with regard to ivermectin (6 mcg/kg). Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death.
HEARTGARD dog medication demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of HEARTGARD products in dogs, including Collies, when used as recommended.
HEARTGARD Plus has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with HEARTGARD Plus in a heartworm disease in dogs preventive program.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.
HEARTGARD Plus for dogs to treat heartworm disease in dogs is available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes in convenient cartons of 6 and 12 chewables.
®HEARTGARD and the Dog & Hand logo are registered trademarks of Merial.
For customer assistance, please contact Merial at 1-888-637-4251.
Marketed by Merial Limited, Duluth, GA 30096-4640
Merial Limited, a company limited by shares registered in England and Wales [registered number 3332751] with a registered office at PO Box 327, Sandringham House, Sandringham Avenue, Harlow Business Park, Harlow Essex CM19 5QA, England, and domesticated in Delaware, USA as Merial LLC, with a place of business at 3239 Satellite Blvd., Duluth, GA 30096-4640 USA.
Made in U.S.A.
©2010 Merial. All Rights Reserved.
Rev. April 2010
NAC No.: 11110235