Furosemide 12.5 mg, 100 Tablets is a diuretic and saluretic that aids in the excretion of excess fluids and sodium associated with edema. Furosemide (generic Salix) is often used as a treatment in animals with congestive heart failure, hepatic disease, some renal disease, and other conditions.
Furosemide tablets for dogs are a diuretic-saluretic for prompt relief of edema in dogs. This dog medicine is distributed by: VEDCO, INC.
Order Furosemide 12.5mg and other medicines for dogs from our pet pharmacy online based in Texas. We deal in different ranges of pet prescription medication and prescription drugs for pets.
USE IN DOGS ONLY
Abnormal fluid retention, or edema, is treated with furosemide
Certain forms of Salix and Disal treat cats and horses
Potent diuretic and saluretic to treat edema in dogs
CAUTION: Federal law restricts this pet med to use by or on the order of a licensed veterinarian.
Furosemide is a potent loop diuretic which is a derivative of anthranilic acid.
The structure is: Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranillic acid. Furosemide is pharmaco-dynamically characterized by the following:
1) This dog medicine for edema treatment is administered orally. It is easily absorbed from the intestinal tract and begins to act in 30 to 60 minutes after oral administration.
2) This pet med a loop diuretic which inhibits reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion.
3) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold.
4) A high degree of efficacy, low inherent toxicity and a high therapeutic index.
The therapeutic efficacy of Furosemide Tablets is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug’s rapid absorption and poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Furosemide Tablets for dogs have no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The pet med possesses diuretic activity either in the presence of acidosis or alkalosis.
DOGS – Furosemide Tablets are indicated for the treatment of edema in dogs associated with cardiac insufficiency and acute non-inflammatory tissue edema. In cases of edema in dogs involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy is determined by the clinical pathology producing the edema.
Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant animals. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia.
Corticosteroids cause an additive potassium-depletion effect.
Furosemide Tablets for dogs are a highly effective diuretic-saluretic which, if given in excessive amounts, may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule of this dog medication may have to be adjusted to the patient’s need. The animal should be observed for early signs of electrolyte imbalance, and corrective measures administered. Early signs of electrolyte imbalance are increased thirst, lethargy, drowsiness or restlessness, fatigue, oliguria, gastro-intestinal disturbances and tachycardia. Special attention should be given to potassium levels. Furosemide Tablets may lower serum calcium levels and cause tetany in rare cases of animals having an existing hypocalcemic tendency.
Furosemide Tablets are contraindicated in anuria. Therapy should be discontinued in cases of progressive renal disease if increasing azotemia and oliguria occur during the treatment. Sudden alterations of fluid and electrolyte imbalance in an animal with cirrhosis may precipitate hepatic coma, therefore, observation during period of therapy is necessary. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved or corrected. Potassium supplementation may be necessary in cases routinely treated with potassium-depleting steroids.
Active or latent diabetes may on rare occasions be exacerbated by furosemide. Transient loss of auditory capacity has been experimentally produced in cats following intravenous injections of excessive doses of furosemide at a very rapid rate.
Furosemide Tablets for dogs to treat edema are a highly effective diuretic and, if given in excessive amounts, as with any diuretic, may lead to excessive diuresis which could result in electrolyte imbalance, dehydration and reduction of plasma volume, enhancing the risk of circulatory collapse, thrombosis and embolism. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids.
Correct potassium deficiency with proper dietary supplementation. If animal needs potassium supplements, use oral liquid form, do not use enteric-coated potassium tablets.
The concurrent use of furosemide with some antibiotics may be inadvisable. There is evidence that the dog medicine enhances the nephrotoxic potential of aminoglycosides, cephalosporins and polymyxins and increases the ototoxic effects of aminoglycosides. Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with Furosemide Tablets and it is advisable to discontinue Furosemide Tablets for one day prior to any elective surgery.
NOT FOR ANIMALS INTENDED FOR FOOD.
DOSAGE AND ADMINISTRATION:
The usual dosage of Furosemide Tablets is 1 to 2 mg/lb body weight (approximately 2.5 to 5 mg/kg). A prompt diuresis usually ensues from the initial treatment.
Administer this dog medicine for edema treatment orally once or twice daily at 6 to 8 hour intervals. The dosage should be adjusted to the individual’s response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1.0 mg per pound of body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration of this pet meds can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema in dogs may be most efficiently and safely accomplished by utilizing an intermittent daily dose schedule, i.e., every other day or 2 to 4 consecutive days weekly.
Diuretic therapy should be discontinued after reduction of the edema in dogs, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema in dogs. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with the client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.
DOG: One-half to one 50 mg scored tablet per 25 pounds body weight. One 12.5 mg scored tablet per 5 to 10 pounds body weight.
Administer this dog medicine once or twice daily, permitting a 6- to 8-hour interval between treatments. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 mg per pound body weight as recommended in preceding paragraphs, “Dosage and Administration”.
HOW SUPPLIED: Oral: Tablets
12.5 mg Tablets – Each tablet contains furosemide 12.5 mg
50 mg Tablets – Each tablet contains furosemide 50 mg
Available in bottles of 500 tablets
TOXICOLOGY: Furosemide tablets demonstrate a very low order of either acute or chronic toxicity. The drug is rapidly absorbed and excreted by both glomerular filtration and tubular secretion. The rates of excretion are of such magnitude that cumulation of furosemide does not occur despite repeated administrations.
The main effect observed in clinical toxicity is an abnormality of fluid and electrolyte imbalances. Ototoxicity resulting in transient loss of hearing has been reported with furosemide.
A safety study was performed in dogs to determine the effects of Furosemide Tablets for dogs at increasing dosages and time elements. The dosage levels were 2 mg/lb body weight (upper recommended dosage), 6 mg/lb body weight (3X upper recommended dosage) and 10 mg/lb body weight (5X upper recommended dosage). The treatment period of this dog medicine ranged up to nine days in length. Results demonstrate a mild dehydration at the 5X level with a slight elevation of hemoglobin and hematocrit levels. Serum levels of potassium and chloride were slightly lowered in the higher dosage groups. Cumulative evaluation of the data demonstrates that Furosemide Tablets are safe when administered at the upper level of the recommended dosage for duration of nine consecutive days.
Store this dog medicine for edema treatment at controlled room temperature (59°-86°F).
KEEP OUT OF REACH OF CHILDREN
Distributed by: VEDCO, INC., St. Joseph, MO 64507
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