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Drontal Plus for Dogs (Rx)

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Product Description

Drontal Plus for Dogs greater than 45 lbs, 30 Tablets is a broad-spectrum dewormer that works against the four primary intestinal parasites in dogs.

This pet dewormer for dogs contains three active ingredients having different modes of action and spectra of activity.

Praziquantel interferes with the tapeworm’s ability to withstand digestion in the intestines. Pyrantel pamoate causes paralysis in roundworms and hookworms in dogs.

Febantel works against whipworms in dogs by stopping their metabolism so they can be passed in the stool.

This pet medicine is clinically proven to be highly effective against intestinal parasites in dogs and has low incidence of side effects. Drontal Plus is FDA-approved for eliminating these intestinal parasites from dogs and puppies at least 3 weeks old and weighing at least 2 lbs.

Now you can order dog medicines online and other pet meds and get the medication for pets delivered right at your doorstep. At our online pharmacy for pets based in Texas, you can buy dog medicine online and lots more.




  • Drontal Plus has three active ingredients to combat intestinal parasites in dogs
  • Eliminates tapeworms, roundworms, whipworms and hookworms in dogs
  • Scored, easy-to-administer chewable tablets
  • Requires one easy dose of a chewable tablet


Federal (U.S.A.) law restricts this pet medicine to use by or on the order of a licensed veterinarian.

Drontal® Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Dewormer are available in three sizes. Each size is scored for convenient oral administration.

Each Drontal® Plus Tablet for Puppies and Small Dogs contains 22.7 mg praziquantel, 22.7 mg pyrantel base as pyrantel pamoate and 113.4 mg febantel.

Each Drontal® Plus Tablet for Medium Sized Dogs contains 68.0 mg praziquantel, 68.0 mg pyrantel base as pyrantel pamoate and 340.2 mg febantel.

Each Drontal® Plus Tablet for Large Dogs contains 136.0 mg praziquantel, 136.0 mg pyrantel base as pyrantel pamoate and 680.4 mg febantel.


This pet dewormer by Bayer Animal Health contains three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited.

Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host.

Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms is digested and is not found in the feces.

Pyrantel pamoate is active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the intestinal parasites in dogs.

Febantel is active against nematode parasites including whipworms in dogs. Febantel is rapidly absorbed and metabolized in the animal. Available information suggests that the parasite’s energy metabolism is blocked, leading to energy exchange breakdown and inhibited glucose uptake.

Laboratory efficacy and clinical studies conducted with this pet dewormer demonstrate that each of the three active ingredients act independently without interference. The combined tablet formulation provides a wide spectrum of activity against the indicated species of intestinal helminths.


Drontal® Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Anthelmintic Tablets are indicated for removal of tapeworms, hookworms and whipworms in dogs.


DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive days with 3 times the labeled dosage rate) of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities.

The effects of this dewormer for dogs on pregnant animals have not been determined. There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.



The presence of intestinal parasites in dogs should be confirmed by laboratory fecal examination. Weigh the animal before treatment. Administer the proper dosage of this dog medicine as specified in the following table as a single oral treatment.


Drontal® Plus Tablets for Puppies and Small Dogs* (2 – 25 lbs.)Drontal® Plus Tablets for Medium Sized Dogs (26 – 60 lbs.)Drontal® Plus Tablets for Large Dogs (45 lbs. and greater)
Body Wt. (lbs.)No. of TabletsBody Wt. (lbs.)No. of TabletsBody Wt. (lbs.)No. of Tablets
2 – 40.526 – 301.045 – 601.0
5 – 71.031 – 441.561 – 901.5
8 – 121.545 – 602.091 – 1202.0
13 – 182.0
19 – 252.5



Drontal®Plus Dewormer for dogs have been developed for oral administration. These chewable tablets may be given directly by mouth or offered in a small amount of food. Fasting is neither necessary nor recommended prior to or after treatment.


For those animals living where reinfections are likely to occur, clients should be instructed in the steps to optimize prevention; otherwise, retreatment may be necessary. This is true in cases of Dipylidium caninum where reinfection is almost certain to occur if fleas are not removed from the animal and its environment. In addition, for control of Echinococcus multilocularis, a program of regular treatment every 21 to 26 days may be indicated (see E. multilocularis section below).


Echinococcus multilocularis is a tapeworm species usually found in wild canids, including foxes, coyotes and wolves. The parasite has also been identified in domestic dogs and cats and is potentially a serious public health concern because it may infect humans.

The life cycle of the parasite is based on a predator-prey relationship as depicted.

The adult tapeworm is small (1-4mm) and resides in the intestinal tract of the definitive host (wild or domestic canid). Eggs from the adult tapeworm are shed in the feces. Rodents such as mice and voles serve as the intermediate host. Eggs ingested by rodents develop in the liver, lungs and other organs to form multilocular cysts. The life cycle is completed after a canid consumes a rodent infected with cysts. Larvae within the cyst develop into adult tapeworms in the intestinal tract of the canid. Eggs may be passed in the feces of the canid approximately 28 days later.

This parasite poses a serious public health problem because of the possibility for human involvement in the life cycle. If eggs shed by an infected canid are accidentally ingested, a highly pathogenic condition (Alveolar Hydatid Disease) results from development of the cyst stage in humans.

The original geographic distribution of E. multilocularis was primarily confined to northern areas of North America. Current evidence indicates migration of the parasite well into the continental United States.

Domestic dogs living in E. multilocularis endemic areas that roam freely with the opportunity to catch wild rodents are at risk of infection. Pet owners should be advised on how to minimize this risk. Proper restraint of dogs should be encouraged, along with regular treatment with dewormer for dogs, following the dosing schedule aforementioned and precautions indicated below.

Additional information on the life cycle and epidemiology of this parasite is available in veterinary parasitology texts.


Diagnosis of E. multilocularis in canids is difficult. The adult tapeworm produces no clinical signs of infection. Tapeworm segments (proglottids) are usually not observed in the feces.

E. multilocularis eggs, observed using microscopic fecal examination procedures, are similar in appearance to those of common species such as Taenia pisiformis.

Assistance in the diagnosis of E. multilocularis may be available from a state veterinary diagnostic laboratory.

Additional information regarding areas where E. multilocularis is suspected or has been confirmed may be obtained from area veterinary schools or the Centers for Disease Control in Atlanta, GA.


Dogs infected with E. multilocularis should be treated to prevent exposure of humans to infective eggs and to break the parasite’s life cycle. The dosage of this pet dewormer for removal of E. multilocularis is the same as that indicated for the removal of the other tapeworm species listed on the label. Laboratory efficacy studies have demonstrated the recommended dosage is 100% effective.

Under condition of continual exposure to wild rodents, retreatment of the dog with this dog medicine at 21-26 day intervals is recommended to prevent the shedding of infectious eggs.


Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with Drontal® Plus Chewable Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. If these procedures are not possible, the eggs can be destroyed by soaking the feces in a sodium hypochlorite (bleach) solution of 3.75% or greater.

All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.


A total of 176 dogs and puppies with naturally acquired or experimental intestinal parasites in dogs were included in 4 well-controlled laboratory studies to establish the efficacy of Drontal® Plus Chewable Tablets for dogs. In addition, 103 dogs and puppies were included in clinical field studies conducted in 5 veterinary clinics at different geographic locations throughout the United States to further evaluate safety and efficacy. These studies included dogs of various sizes, ages and breeds. Data from these studies demonstrated Drontal Plus for dogs are safe and efficacious for the removal of the intestinal parasites in dogs indicated on the label when used as directed. Results obtained in the laboratory and clinical studies indicate small numbers of hookworm or roundworm eggs may be passed in the feces for up to 7 days after treatment although the worms themselves were eliminated. A follow-up fecal examination should be conducted 2 to 4 weeks after treatment to determine the need for retreatment with broad-spectrum dewormer for dogs.

drontal dewormer


None of the 103 dogs treated with Drontal Plus for dogs Anthelmintic Chewable Tablets in the clinical field studies exhibited drug-related side effects.

For customer service or to obtain product information, including Material Safety Data Sheet, call 1-800-633-3796. For medical emergencies or to report adverse reactions, call 1-800-422-9874.


Controlled safety evaluations have been conducted in dogs with Drontal® Plus (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Anthelmintic Chewable Tablets. Dogs receiving this pet dewormer up to 5 times the label dosage (35 mg praziquantel, 35 mg pyrantel pamoate and 179 mg febantel per kg of body weight) for 3 consecutive days (3 times the label duration) showed clinical signs of vomiting and non-formed stools. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings (outside of normal range) at 6 days post-treatment with this dewormer for dogs. No additional findings were noted in hematology/clinical chemistry parameters nor were there any treatment-related histological lesions. Vomiting was the only side effect observed when dogs received a single treatment of 61 mg praziquantel, 61 mg pyrantel pamoate and 305 mg febantel/kg with one dog having an elevated SGPT reading (outside of normal range) at 24 hours post-treatment which had returned to normal by 7 days.




Drontal Plus for dogs should be stored at controlled room temperatures between 59-86°F (15-30°C).


Each chewable tablet size is available in bottles of 50 (puppies and small dogs, medium sized dogs) or 30 (large dogs).

Code 08713130-17609950 Tablets/Bottle (Puppies and Small Dogs)
Code 08713149-17709950 Tablets/Bottle (Medium Sized Dogs)
Code 0872463930 Tablets/Bottle (Large Dogs)

Bayer, the Bayer Cross, and Drontal are trademarks of Bayer.

Bayer HealthCare LLC, Animal Health

Division, Shawnee Mission, Kansas 66201 USA

NADA 141-007, Approved by FDA

©2007 Bayer HealthCare LLC

May, 2007

08954340, R.1


Regulations for product use are established by country. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. Before using or dispensing any product, read and carefully observe the label directions.

Additional Information

Bottle Size

136mg – 30 Chewables, Large, 136mg – 30 Tablets, 22.7mg – 40 Chewables, Small, 22.7mg – 50 Tablets, 68mg – 40 Chewables, Med, 68mg – 50 Tablets

Product Type

Nutrition Medicine, OTC Medicine, Rx Medicine


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