As in humans, your pet’s liver is one of the largest organs in its body and it performs many life essential functions. With Denosyl SD4 you can protect liver cells of your pet from dying and is helpful in cell repair and healing.
Denosyl SD4 elevates liver glutathione, the liver’s main detoxifier, as well as supports overall liver health.
This is a liver supplement for pet for use to aid in managing a variety of liver problems in dogs and cats. This supplement for pet may be used as an adjunct therapy for dogs and cats with elevated liver enzymes and suffering from: hepatic lipidosis, breed-specific chronic hepatitis, feline liver disease, Cushing’s Disease, Inflammatory Bowel Disease, Pancreatitis, etc.
Denosyl SD4 has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione antioxidant is the liver’s main detoxifier that protects hepatic cells from toxins and death.
The active ingredient in Denosyl 225 mg, 30 Tablets, S-Adenosylmethionine (SAMe), supports healthy liver functions in cats and dogs. SAMe supplements raise levels of the glutathione antioxidant in the liver.
Denosyl by NUTRAMAX LABORATORIES, INC is available in three strengths: as an enteric-coated 90 mg, 225 mg, and 425 mg tablet of active S-Adenosylmethionine.
Because S-Adenosylmethionine is extremely sensitive to moisture, tablets are individually sealed in specialized moisture-resistant blister packs.
You can order the liver supplement for pet and other prescription drugs for pets at pet drugs online shop. At our Texas based pet pharmacy online, we offer quality pet prescription medication for your beloved pet.
Dogs and Cats
- Boosts the presence of antioxidant glutathione in the liver
- Ensures healthy liver function in dogs and cats
- Useful in instances when your pet’s liver function is not optimally
- May help damaged liver cells repair themselves
- Easy-to-administer supplement for pet
S-Adenosylmethionine is an endogenous molecule synthesized by cells throughout the body and is formed from the amino acid methionine and ATP. It is an essential part of three major biochemical pathways: transmethylation, transsulfuration and aminopropylation. As part of these pathways, S-Adenosylmethionine is essential to all cells and is particularly important in hepatocytes because of their central role in metabolism. A deficiency of S-Adenosylmethionine, therefore, may initiate or contribute to abnormalities of cellular structure and function in the liver as well as many other body tissues. This can cause liver disease in cats and dogs.
Conversely, exogenous administration of S-Adenosylmethionine has been shown to result in improvements in hepatocellular function in both in vivo and in vitro studies, without cytotoxicity or significant side effects.
Precursors of S-Adenosylmethionine do not have similar effects. Administration of methionine to animals with decreased liver function may not increase hepatic S-Adenosylmethionine levels and may be toxic.
The best way to increase S-Adenosylmethionine levels in the body is by direct supplementation with S-Adenosylmethionine.
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs.
Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. A study found that low liver glutathione concentrations are common in dogs and cats with decreased hepatobiliary function.
Denosyl is recommended to improve hepatic glutathione levels in patients to help maintain and prevent liver problems in dogs and cats. Denosyl may also be used in other areas of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduce glutathione antioxidant concentrations.
Denosyl, however, goes beyond increasing liver glutathione levels and has been shown to protect liver cells from cell death and may be useful in cell regeneration.
A study has also shown that Denosyl supplement for pet may improve bile flow in cats.
In a pharmacokinetic study with fasted dogs given Denosyl liver supplement for pet, peak plasma levels were recorded within 4 hours of administration.
A pharmacokinetic study in fasted cats showed peak plasma levels at 2-4 hours post Denosyl administration.
Denosyl demonstrates an exceptionally wide margin of safety. Oral acute toxicity studies in rats indicated an LD50 greater than 4,640 mg/kg.
Clinically healthy dogs administered 20 mg/kg/day of Denosyl liver supplement for pet for 6 weeks and clinically healthy cats administered Denosyl at 2 times the recommended daily amount for 113 days remained healthy with no adverse effects from administration of Denosyl.
Administration as a Nutritional Supplement
Because the enteric-coated tablet for dog must be kept intact to prevent destruction by stomach acid, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration of this pet medicine may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.
For optimal absorption, the pet med tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denosyl® tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.
Denosyl 90 mg tablets for cats are ideal because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.
FELINE AND CANINE DENOSYL DAILY* ADMINISTRATION GUIDE
For Cats and Small Dogs
|Body Weight||90 mg Denosyl|
|Up to 12||Up to 5.5||One tablet|
For Medium Dogs
|Body Weight||90 mg Denosyl|
|13 to 34||6 to 15.5||One tablet|
For Large Dogs
|Body Weight||90 mg Denosyl|
|35 to 65||16 to 29.5||One tablet|
|66 to 120||30 to 54.5||Two tablet|
|Over 120||Over 54.5||Three tablet|
*The number of tablets can be gradually reduced or increased at any time depending on the pet’s needs. Many pets are maintained long-term on every-other-day or every-third-day administration.
FOR CATS and SMALL DOGS90 mg – 30 stabilized tablets01-1007-01
|FOR MEDIUM DOGS||225 mg – 30 stabilized tablets||01-1008-01|
|FOR LARGER DOGS||30 to 54.5||Two tablet|
|FOR LARGER DOGS||425 mg – 30 stabilized tablets||01-1014-0|
Any questions or comments?
Call toll-free 1-800-925-5187
NUTRAMAX LABORATORIES, INC., 2208 Lakeside Boulevard, Edgewood, Maryland 21040