Buy Clomicalm Online, rx medicine for dogs

Clomicalm (Rx)

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Product Description

Anxiety in dogs can lead to most common dog behavior problems. To treat separation anxiety in dogs Clomicalm 20 mg, Blue, 30 Tablets, manufactured by Novartis Animal Health US, Inc., is very effective.

This dog medicine is a tricyclic antidepressant (clomipramine), which is effective for treating separation anxiety in dogs. This prescription drugs for pets is very effective when used in conjunction with a behavior management modification plan.

You can order this antidepressant for dogs as well as other dog medicines and other pet prescription medication from our pet pharmacy online. Based in Texas, our online drug store understands the importance of pet in your life and offers the best services in pet medications.




Federal (USA) law restricts this dog medication to use by or on the order of a licensed veterinarian.


  • Tricylclic antidepressant for dogs
  • Used to treat separation anxiety in dogs
  • Minimizes symptoms of canine separation anxiety

Novartis CLOMICALM (clomipramine hydrochloride) dog anxiety tablets belong to the dibenzazepine class of tricyclic antidepressants. These dog medicines are oblong, light brown in color and contain clomipramine hydrochloride formulated together with meat components.

Indications and Usage:

CLOMICALM Tablets are to be used as part of a comprehensive behavioral management program to treat separation anxiety in dogs greater than 6 months of age.

Inappropriate barking or destructive behavior, as well as inappropriate elimination (urination or defecation) due to anxiety in dogs may be alleviated by the use of CLOMICALM Tablets in conjunction with behavior modification.

Separation anxiety in dogs is a complex behavior disorder displayed when the owner (or other attachment figure) leaves the dog. The signs of separation anxiety in dogs evaluated in controlled trials were vocalization, destructive behavior, excessive salivation, and inappropriate elimination. In the absence of the owner or attachment figure, dogs with separation anxiety may exhibit one or more of these clinical signs. Although the owner (attachment figure) may inadvertently misinterpret this behavior, which only happens in their absence, as spiteful, it is thought to be the result of anxiety experienced by the dog. Punishment is not considered appropriate for a dog with separation anxiety.

Proper recognition of clinical signs of dog anxiety, including a complete patient history and assessment of the patient’s household environment, is essential to accurately diagnose and treat canine separation anxiety.

The use of CLOMICALM Tablets should not replace appropriate behavioral management and environmental management but should be used to facilitate a comprehensive behavior management program.


CLOMICALM Tablets are contraindicated in dogs with known hypersensitivity to clomipramine or other tricyclic antidepressants for dogs.

CLOMICALM Tablets should not be used in male breeding dogs. Testicular hypoplasia was seen in dogs treated for 1 year at 12.5 times the maximum daily dose.

CLOMICALM Tablets should not be given in combination, or within 14 days before or after treatment with a monoamine oxidase inhibitor [e.g., selegiline hydrochloride (L-deprenyl), amitraz]. CLOMICALM Tablets are contraindicated for use in dogs with a history of seizures or concomitantly with drugs which lower the seizure threshold.

Human Warnings:

This dog medication for anxiety is not for use in humans. Keep out of reach of children. In case of accidental ingestion seek medical attention immediately. In children, accidental ingestion should be regarded as serious. There is no specific antidote for clomipramine. Overdose in humans causes anticholinergic effects including effects on the central nervous (e.g., convulsions) and cardiovascular (e.g., arrhythmia, tachycardia) systems.

People with known hypersensitivity to clomipramine should administer the product with caution.



CLOMICALM dog medication is not recommended for other behavior problems, such as aggression (see Adverse Reactions). Studies to establish the safety and efficacy of CLOMICALM Tablets in dogs less than 6 months of age have not been conducted.


It is critical to conduct a comprehensive physical examination, including appropriate laboratory tests, and to obtain a thorough history and assessment of the patient’s household environment, to rule-out causes of inappropriate behavior unrelated to canine separation anxiety before prescribing CLOMICALM Tablets. Periodic reassessment of hematological and serum biochemical data during the administration of this medication is advised. Veterinarians should be familiar with the risks and benefits of the treatment of behavioral disorders in dogs before initiating therapy. Inappropriate use of CLOMICALM Tablets, i.e., in the absence of a diagnosis or without concurrent behavioral modification, may expose the animal to unnecessary adverse effects and may not provide any lasting benefit of therapy.

Drug Interactions:

Recommendations on the interaction between clomipramine and other medications are extrapolated from data generated in humans. Plasma concentrations of clomipramine have been reported to be increased by the concomitant administration of phenobarbital. Plasma levels of closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine). Plasma levels of closely related tricyclic antidepressants have been reported to be decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin). Caution is advised in using clomipramine with anticholinergic or sympathomimetic drugs or with other CNS-active drugs, including general anesthetics and neuroleptics.

Prior to elective surgery with general anesthetics, clomipramine should be discontinued for as long as clinically feasible.

Use in Concomitant Illness:

Use with caution in dogs with cardiovascular disease. At 20 mg/kg/day (5X the maximum recommended dose), bradycardia and arrhythmias (atrioventricular node block and ventricular extrasystole) were observed in dogs. Because of its anticholinergic properties, clomipramine should be used with caution in patients with increased intraocular pressure, a history of narrow angle glaucoma, urinary retention or reduced gastrointestinal motility. Because clomipramine is principally metabolized in the liver, caution is advised in using this dog anxiety medication in the presence of preexisting liver disease.

Reproductive Safety:

Safety studies to determine the effects of CLOMICALM Tablets in pregnant or lactating female dogs have not been conducted. These tablets for dogs should not be used in breeding males (See Contraindications).


Dose Establishment:

A 12 week, placebo-controlled, multi-site clinical trial was conducted in the US and Europe to establish an effective dose of CLOMICALM Tablets in dogs. Treatment with CLOMICALM Tablets, at 2 – 4 mg/kg/day divided twice daily, in conjunction with behavioral modification (desensitization and counterconditioning) was more effective than behavior modification alone in reducing the signs of separation anxiety in dogs.

Dose Confirmation:

In another placebo-controlled, multi-site clinical trial, CLOMICALM Tablets at 2 – 4 mg/kg/day given either once daily or divided twice daily showed significant improvement in resolving signs of separation anxiety in dogs when tested against behavioral modification alone (desensitization and counterconditioning).

In this 8 week study, the rate of improvement of the dogs receiving CLOMICALM Tablets with behavioral management modification was significantly faster than the rate of improvement of the dogs receiving behavioral modification alone. After one week on trial, 47% of the dogs receiving CLOMICALM tablets once or twice (divided dose) daily in conjunction with behavioral modification showed clinical improvement compared to improvement in 29% of the dogs receiving behavioral modification alone.


CLOMICALM Tablets for dogs were demonstrated to be well-tolerated in dogs at the recommended label dose of 2-4 mg/kg/day. In a six month target animal safety study, beagle dogs were dosed daily at 4 (1X), 12 (3X), and 20 (5X) mg/kg/day. Emesis was seen in all groups including the dogs receiving placebo, but occurred more frequently in dogs receiving 12 and 20 mg/kg. Decreased activity was also seen in dogs receiving the 12 and 20 mg/kg. There were no apparent treatment-related alterations in the following: body weights, physical examination findings, electrocardiograph examinations, hematology or biochemistry parameters, ophthalmoscopic examinations, macroscopic or microscopic organ examinations and organ weights. Average food and water consumption over the 26 week period was similar for control and treated groups. In a one year study, pure bred dogs were dosed daily at 12.5 (3X), 50 (12.5X), and 100 (25X) mg/kg/day. Emesis and mydriasis were observed within 15 minutes to one hour after dosing in dogs receiving 12.5, 50, and 100 mg/kg/day and lethargy was observed within 1 hour of dosing in dogs receiving 50 and 100 mg/kg. Testicular hypoplasia was seen in dogs receiving 50 mg/kg. At 100 mg/kg/day (25X) convulsions and eventual death occurred in five out of the eight dogs.

Adverse Reactions:

Frequency and category of adverse reactions observed in dogs dosed with CLOMICALM tablets to treat anxiety in dogs.

Tablets or placebo were observed in multisite clinical studies as follows.

Adverse Reactions Reported in Placebo-Controlled Clinical Field Trials
CLOMICALM N=180Placebo N=88
Emesis36 (20%)8 (9%)
Lethargy26 (14%)7 (8%)
Diarrhea17 (9%)4 (5%)
Polydipsia6 (3%)0
Decreased Appetite6 (3%)3 (3%)
Aggression*3 (2%)1 (1%)
Seizure2 (1%)0
Dry Mouth1 (0.5%)1 (1%)
Tremors1 (0.5%)0
Constipation1 (0.5%)0
Anisocoria1 (0.5%)0
Polyuria1 (0.5%)0
Hyperthermia1 (0.5%)0

*These dogs displayed growling behavior towards either humans or other dogs.

Post-Approval Experience:

Although not all adverse reactions are reported, the following adverse reactions are based on voluntary post-approval adverse drug experience reporting: lethargy/depression, anorexia, elevation in liver enzymes, vomiting and diarrhea. Hepatobiliary disease has occurred, especially in the presence of pre-existing conditions or with concurrent administration of drugs metabolized via the hepatic system. Additionally, in an overdose situation, the following signs have been reported: ataxia, anticholinergic effects (e.g., mydriasis, bradycardia, tachycardia, and arrhythmia) and vocalization.

Dosage and Administration:

The recommended daily dose of CLOMICALM Tablets for dogs is 2 to 4 mg/kg/day (0.9-1.8 mg/lb/day) (see dosing table below). It can be administered as a single daily dose or divided twice daily based on patient response and/or tolerance of the side effects. It may be prudent to initiate treatment in divided doses to minimize side effects by permitting tolerance to side effects to develop or allowing the patient time to adapt if tolerance does not develop. To reduce the incidence of vomiting that may be experienced by some dogs, CLOMICALM dog medicine may be given with a small amount of food.

Dog Weight (lbs)CLOMICALM per DayNo. Tablets per DayTablet Strength
2.75-5.55 mg15 mg
5.6-10.910 mg25 mg
11-2220 mg120 mg
22.1-4440 mg140 mg
44.1-8880 mg180 mg
88.1-176160 mg280 mg

The specific methods of behavioral modification used in clinical trials involved desensitization and counter conditioning techniques. Since the manifestation of separation anxiety in dogs can vary according to the individual dog, it is advised that a specific behavior modification plan be developed based on a professional assessment of each individual case. Once the desired clinical effect is achieved and the owners have successfully instituted the appropriate behavioral management modification, the dose of CLOMICALM Tablets for dogs may be reduced to maintain the desired effect or discontinued. Withdrawal side effects were not reported in studies with CLOMICALM Tablets in dogs.

However, in clinical practice, it is recommended to taper the individual patient dose while continuing to monitor the dog’s behavior and clinical status through the dose reduction or withdrawal period. Continued behavioral management modification is recommended to prevent recurrence of the clinical signs of anxiety in dogs.

The effectiveness and clinical safety of CLOMICALM Tablets for long-term use (i.e., for more than 12 weeks) has not been evaluated.

Professional judgment should be used in monitoring the patient’s clinical status, response to therapy and tolerance to side effects to determine the need to continue treatment with CLOMICALM dog anxiety medication and to continue to rule-out physiological disorders which may complicate the diagnosis and treatment of canine separation anxiety.

Storage Conditions:

Store this dog anxiety medication in a dry place at controlled room temperature, between 59° and 77°F (15-25°C).

How Supplied:

CLOMICALM dog tablets are available in 5, 20, 40 and 80 mg tablet strengths in color-coded packaging for oral administration to dogs.

Keep this and all prescription drugs for pets out of reach of children.

Manufactured for: Novartis Animal Health US, Inc., Greensboro, NC 27408, USA

Additional Information

Bottle Size

20mg 30 Caplets, 5mg 30 Caplets, 80mg 30 Caplets

Product Type

Nutrition Medicine, OTC Medicine, Rx Medicine


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