Clindamycin Hydrochloride Drops, 25 mg/mL, 20 mL is a broad-spectrum antibiotic used to treat a variety of infection in dog and cat. Clindamycin pet meds are effective against skin infection in cats and dogs as well as infected wounds and abscesses, dental infection in dogs, and other soft tissue infections.
This antibiotic for pets (clindamycin hydrochloride liquid) contains clindamycin hydrochloride which is the hydrated salt of clindamycin. Clindamycin is a semisynthetic antibiotic, manufactured by First Priority, Inc.
It is a palatable formulation intended for oral administration in both cats and dogs. Each mL of Clindamycin Hydrochloride Drops contains clindamycin hydrochloride equivalent to 25 mg clindamycin; and ethyl alcohol, 8.64%.
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Dogs and Cats
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
- Clindamycin antibiotics for pets
- Easy-to-administer oral antibiotic drops
- Treats a variety of bacterial infections
- Treat dog skin problems, skin infection in cats and lots more
Clindamycin Hydrochloride antibiotic for pets (for use in dogs and cats) is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below:
Skin infections in dogs (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Dental infection in dogs due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens.
Skin infections in cats (wounds and abscesses) due to Staphylococcus aureus, Staphylococcus intermedius and Streptococcus spp. Deep wounds and infections due to Clostridium perfringens and Bacteroides fragilis. Dental infections in cats due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., Clostridium perfringens and Bacteroides fragilis.
DOSAGE AND ADMINISTRATION
Infected Wounds, Abscesses and Dental Infections
Oral: 2.5 – 15.0 mg/lb body weight every 12 hours.
Duration: Treatment with Clindamycin Hydrochloride antibiotic for pets may be continued up to a maximum of 28 days if clinical judgment indicates. Treatment of acute infection in dog and cat should not be continued for more than three or four days if no response to therapy is seen.
Clindamycin Hydrochloride Drops, administer 1-6 mL/10 lbs body weight every 12 hours.
Duration: Treatment with Clindamycin Hydrochloride antibiotic for pets is recommended for a minimum of 28 days. This pet medications treatment should not be continued for longer than 28 days if no response to therapy is seen.
Clindamycin Hydrochloride Drops, administer 2-6 mL/10 lbs body weight every 12 hours.
Infected Wounds, Abscesses and Dental Infections
5.0 – 15.0 mg/lb body weight once every 24 hours depending on the severity of the condition.
Duration: Treatment with Clindamycin Hydrochloride Drops may be continued up to a maximum of 14 days if clinical judgment indicates. Treatment of acute infection in dog and cat should not be continued for more than three to four days if no clinical response to therapy is seen.
Clindamycin Hydrochloride Drops, to provide 5.0 mg/lb, administer 1 mL/5 lbs body weight once every 24 hours; to provide 15.0 mg/lb, administer 3 mL/5 lbs body weight once every 24 hours.
Clindamycin Hydrochloride antibiotic for cats and dogs is contraindicated in animals with a history of hypersensitivity to preparations containing clindamycin or lincomycin. Because of potential adverse gastrointestinal effects, do not administer to rabbits, hamsters, guinea pigs, horses, chinchillas or ruminating animals.
Keep this antibiotic for pets out of reach of children. Not for human use.
During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed.
The use of Clindamycin Hydrochloride antibiotic drops occasionally results in overgrowth of non-susceptible organisms such as clostridia and yeasts. Therefore, the administration of Clindamycin Hydrochloride Drops should be avoided in those species sensitive to the gastrointestinal effects of clindamycin. Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation.
Patients with very severe renal disease and/or very severe hepatic disease accompanied by severe metabolic aberrations should be dosed with caution, and serum clindamycin levels monitored during high-dose therapy.
Clindamycin hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, Clindamycin Hydrochloride pet medication should be used with caution in animals receiving such agents.
Safety in gestating bitches and queens or breeding male dogs and cats has not been established.
Side effects occasionally observed in either clinical trials or during clinical use were vomiting and diarrhea.
To report a suspected adverse reaction or to request a material safety data sheet (MSDS) of this antibiotic for pets call 1-800-650-4899.
Site and Mode of Action: Clindamycin is an inhibitor of protein synthesis in the bacterial cell. The site of binding appears to be in the 50S sub-unit of the ribosome. Binding occurs to the soluble RNA fraction of certain ribosomes, thereby inhibiting the binding of amino acids to those ribosomes. Clindamycin differs from cell wall inhibitors in that it causes irreversible modification of the protein-synthesizing sub cellular elements at the ribosomal level.
Microbiology: Clindamycin is a lincosaminide antimicrobial agent with activity against a wide variety of aerobic and anaerobic bacteria pathogens. Clindamycin is a bacteriostatic compound that inhibits bacterial protein synthesis by binding to 50S ribosomal sub-unit. The minimum inhibitory concentrations (MICs) of Gram-positive and obligate anaerobic pathogens isolated from dogs and cats in the United States are presented in Table 1 and Table 2. Bacteria were isolated in 1998-1999. All MICs were performed in accordance with the National Committee for Clinical Laboratory Standards (NCCLS).
Table 1. Clindamycin MIC Values (μg/mL) from Diagnostic Laboratory Survey Data Evaluating Canine Pathogens in the U.S. During 1998-99
|Organism||Number of Isolates||MIC50||MIC85||MIC90||Range|
- The correlation between the in vitro susceptibility data and clinical response has not been determined.
- Soft Tissue/Wound: includes samples labeled wound, abscess, aspirate, exudates, draining tract, lesion, and mass
- Osteomyelitis/Bone: includes samples labeled bone, fracture, joint, tendon
- No range, all isolates yielded the same value
- Dermal/Skin: includes samples labeled skin, skin swab, biopsy, incision, lip
Table 2. Clindamycin MIC Values (μg/mL) from Diagnostic Laboratory Survey Data Evaluating Feline Pathogens from Wound and Abscess Samples in the U.S. During 1998
|Organism||Number of Isolates||MIC50||MIC90||Range|
The correlation between the in vitro susceptibility data and clinical response has not been determined
Clindamycin Hydrochloride pet medication is available as 20 mL filled in 30 mL bottles (25 mg/mL) supplied in packers containing 12 cartooned bottles with direction labels and calibrated dosing droppers.
Store this antibiotic for pets at controlled room temperature between 20° to 25° C (68° to 77° F) [see USP].
Keep this dog medicine container tightly closed when not in use.
Manufactured for: Clipper Distributing Company, LLC, St. Joseph, MO 64507
Manufactured by: First Priority, Inc., Elgin, IL U.S.A.