Clavamox 125 mg, 210 Tablets is a prescription antibiotic for dogs and cats that is used to treat a wide variety of bacterial infections.
This is an orally administered formulation comprised of the broad-spectrum antibiotic Amoxi® (amoxicillin trihydrate) and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid).
Amoxicillin trihydrate is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative, aerobic and anaerobic microorganisms.
The active ingredient clavulanate potassium in this pet medicine manufactured by SmithKline Beecham Pharmaceuticals makes bacteria that are normally resistant to amoxicillin sensitive to it instead.
You can order this dog mediation, antibiotic for cats and other cat and dog medicines at our pet pharmacy online. Based in Houston, our online drug store understands the importance of pet in your life and offers the best services in discount pet meds.
Dogs and Cats
Federal law restricts this pet meds to use by or on the order of a licensed veterinarian.
- Broad-spectrum antibiotics for cats and dogs
- Treats a variety of bacterial infections
- Effective against skin infections in dogs and cats
Clavamox is stable in the presence of gastric acid and is not significantly influenced by gastric or intestinal contents. The 2 components are rapidly absorbed resulting in amoxicillin and clavulanic acid concentrations in serum, urine, and tissues similar to those produced when each is administered alone.
Amoxicillin and clavulanic acid diffuse readily into most body tissues and fluids with the exception of brain and spinal fluid, which amoxicillin penetrates adequately when meninges are inflamed. Most of the amoxicillin is excreted unchanged in the urine. Clavulanic acid’s penetration into spinal fluid is unknown at this time.
Approximately 15% of the administered dose of clavulanic acid is excreted in the urine within the first 6 hours.
Clavamox combines the distinctive properties of a broad-spectrum pet antibiotic and a β-lactamase inhibitor to effectively extend the antibacterial spectrum of amoxicillin to include β-lactamase-producing as well as non-β-lactamase-producing aerobic and anaerobic organisms.
Amoxicillin is bactericidal in action and acts through the inhibition of biosynthesis of cell wall mucopeptide of susceptible organisms. The action of clavulanic acid extends the antimicrobial spectrum of amoxicillin to include organisms resistant to amoxicillin and other β-lactam antibiotics. Amoxicillin/clavulanate has been shown to have a wide range of activity which includes β-lactamase-producing strains of both gram-positive and gram-negative aerobes, facultative anaerobes, and obligate anaerobes. Many strains of the following organisms, including β-lactamase-producing strains, isolated from veterinary sources, were found to be susceptible to amoxicillin/clavulanate in vitro but the clinical significance of this activity has not been demonstrated for some of these organisms in animals.
Aerobic bacteria, including Staphylococcus aureus*, β-lactamase-producing Staphylococcus aureus* (penicillin resistant), Staphylococcus species*, Staphylococcus epidermidis, Staphylococcus intermedius, Streptococcus faecalis, Streptococcus species*, Corynebacterium pyogenes, Corynebacterium species, Erysipelothrix rhusiopathiae, Bordetella bronchiseptica, Escherichia coli*, Proteus mirabilis, Proteus species, Enterobacterspecies, Klebsiella pneumoniae, Salmonella dublin, Salmonella typhimurium, Pasteurella multocida, Pasteurella hemolytica, Pasteurella species*.
* The susceptibility of these organisms has also been demonstrated in vivo studies.
Studies have demonstrated that both aerobic and anaerobic flora is isolated from gingival cultures of dogs with clinical evidence of canine periodontal disease. Both gram-positive and gram-negative aerobic and anaerobic sub gingival isolates indicate sensitivity to amoxicillin/clavulanic acid during antimicrobial susceptibility testing.
The recommended quantitative disc susceptibility method (FEDERAL REGISTER 37:20527-29; Bauer AW, Kirby WMM, Sherris JC, et al: Antibiotic susceptibility testing by standardized single disc method. Am J Clin Path 45:493, 1966) utilized 30 mcg Augmentin® (AMC) discs for estimating the susceptibility of bacteria to Clavamox Tablets.
Clavamox Tablets are indicated in the treatment of:
Skin infection in dogs and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., and E. coli.
Periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. Clavamox has been shown to be clinically effective for treating cases of canine periodontal disease.
Skin infection in cats and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., E. coli, and Pasteurella spp.
Urinary tract infections (cystitis) due to susceptible strains of E. coli.
Therapy may be initiated with Clavamox prior to obtaining results from bacteriological and susceptibility studies. A culture should be obtained prior to pet antibiotic treatment to determine susceptibility of the organisms to Clavamox. Following determination of susceptibility results and clinical response to medication, therapy may be reevaluated.
The use of this pet antibiotic medicine is contraindicated in animals with a history of allergic reaction to any of the penicillins or cephalosporins.
Clavamox contains semisynthetic penicillin (amoxicillin) and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids.
Safety of use in pregnant or breeding animals of this pet medicine has not been determined. Store this semisynthetic antibiotic medicine in a dry, cool place at temperatures not above 25°C (77°F). Do not remove from foil strip until ready to use.
DOSAGE AND ADMINISTRATION:
The recommended dosage is 6.25 mg/lb of body weight twice a day. Skin infection in dogs and soft tissue infections such as abscesses, cellulitis, wounds, superficial/juvenile pyoderma, and canine periodontal disease should be treated for 5-7 days or for 48 hours after all symptoms have subsided. If no response is seen after 5 days of dog antibiotic treatment, therapy should be discontinued and the case reevaluated. Deep pyoderma may require dog antibiotics treatment for 21 days; the maximum duration of treatment should not exceed 30 days.
The recommended dosage is 62.5 mg twice a day.
Skin infection in cats and soft tissue infections such as abscesses and cellulitis/dermatitis should be treated for 5-7 days or for 48 hours after all symptoms have subsided, not to exceed 30 days. If no response is seen after 3 days of treatment, therapy should be discontinued and the case re-evaluated. Urinary tract infections may require cat antibiotics treatment for 10-14 days or longer. The maximum duration of treatment should not exceed 30 days.
Clavamox antibiotic for pets in the following strengths are supplied in strip packs. Each carton holds 15 strips with 14 antibiotic tablets per strip (210 tablets per carton).
- Each 62.5-mg tablet contains amoxicillin trihydrate equivalent to 50 mg of amoxicillin activity and 12.5 mg of clavulanic acid as the potassium salt. For use in dogs and cats.
- Each 125-mg tablet contains amoxicillin trihydrate equivalent to 100 mg of amoxicillin activity and 25 mg of clavulanic acid as the potassium salt. For use in dogs only.
- Each 250-mg tablet contains amoxicillin trihydrate equivalent to 200 mg of amoxicillin activity and 50 mg of clavulanic acid as the potassium salt. For use in dogs only.
- Each 375-mg tablet contains amoxicillin trihydrate equivalent to 300 mg of amoxicillin activity and 75 mg of clavulanic acid as the potassium salt. For use in dogs only.
Dispense this dog medicine according to recommendations outlined in Dosage and Administration section.
Manufactured by: SmithKline Beecham Pharmaceuticals, Philadelphia, PA 19101
Distributed by: Pfizer Animal Health, Exton, PA 19341, USA