Clavamox Drops, 15 mL is a prescription antibiotic for dogs and cats that is used to treat a wide variety of bacterial infections.
Clavamox (amoxicillin trihydrate/clavulanate potassium) is an orally administered formulation comprised of the broad-spectrum antibiotic Amoxi® (amoxicillin trihydrate) and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid).
Amoxicillin trihydrate is a semisynthetic antibiotic for pets with a broad spectrum antibiotic bactericidal activity against many gram-positive and gram-negative, aerobic and anaerobic microorganisms.
Clavulanate potassium makes bacteria that are normally resistant to amoxicillin sensitive to it instead.
Antibiotics like Clavamox are used to treat skin infections in cats and dogs. Also treats infected wounds, abscesses, cellulitis, and urinary tract infections.
This is the first potentiated penicillin approved for dogs and cats. It is manufactured by SmithKline Beecham Pharmaceuticals.
You can order this dog medication, antibiotic for cats and other cat and dog medicines at our pet pharmacy online. Based in Houston, our online drug store understands the importance of pet in your life and offers the best services in discount pet meds.
Cats and Dogs
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- Broad-spectrum antibiotics for cats and dogs
- Treats skin infection in dogs and cats
- Treats skin injuries, abscesses, and cellulitis
- First potentiated penicillin approved for dogs and cats
- Effective against gram-positive and gram-negative bacteria
Clavamox is stable in the presence of gastric acid and is not significantly influenced by gastric or intestinal contents. The 2 components are rapidly absorbed resulting in amoxicillin and clavulanic acid concentrations in serum, urine, and tissues similar to those produced when each is administered alone.
Amoxicillin and clavulanic acid diffuse readily into most body tissues and fluids with the exception of brain and spinal fluid, which amoxicillin penetrates adequately when meninges are inflamed. Most of the amoxicillin is excreted unchanged in the urine. Clavulanic acid’s penetration into spinal fluid is unknown at this time.
Approximately 15% of the administered dose of clavulanic acid is excreted in the urine within the first 6 hours.
Clavamox combines the distinctive properties of a broad-spectrum antibiotic for pets and a β-lactamase inhibitor to effectively extend the antibacterial spectrum of amoxicillin to include β-lactamase as well as non-β-lactamase-producing aerobic and anaerobic organisms.
SmithKline Beecham Pharmaceuticals
Amoxicillin is bactericidal in action and acts through the inhibition of biosynthesis of cell wall mucopeptide of susceptible organisms. The action of clavulanic acid extends the antimicrobial spectrum of amoxicillin to include organisms resistant to amoxicillin and other β-lactam antibiotics. Amoxicillin/clavulanate has been shown to have a wide range of activity which includes β-lactamase-producing strains of both gram-positive and gram-negative aerobes, facultative anaerobes, and obligate anaerobes. Many strains of the following organisms, including β-lactamase-producing strains, isolated from veterinary sources, were found to be susceptible to amoxicillin/clavulanate in vitro but the clinical significance of this activity has not been demonstrated for some of these organisms in animals.
Aerobic bacteria, including Staphylococcus aureus*, β-lactamase-producing Staphylococcus aureus* (penicillin resistant), Staphylococcus species*,
Staphylococcus epidermidis, Staphylococcus intermedius, Streptococcus faecalis, Streptococcus species*, Corynebacterium pyogenes,Corynebacterium species, Erysipelothrix rhusiopathiae, Bordetella bronchiseptica, Escherichia coli*, Proteus mirabilis, Proteus species, Enterobacter species, Klebsiella pneumoniae, Salmonella dublin, Salmonella typhimurium, Pasteurella multocida*, Pasteurella hemolytica, Pasteurella species*. * The susceptibility of these organisms has also been demonstrated in in vivo studies. Studies have demonstrated that both aerobic and anaerobic flora are isolated from gingival cultures of dogs with clinical evidence of periodontal disease. Both gram-positive and gram-negative aerobic and anaerobic subgingival isolates indicate sensitivity to amoxicillin/clavulanic acid during antimicrobial susceptibility testing.
The recommended quantitative disc susceptibility method (FEDERAL REGISTER 37:20527-29; Bauer AW, Kirby WMM, Sherris JC, et al: Antibiotic susceptibility testing by standardized single disc method. Am J Clin Path 45:493, 1966) utilized 30 mcg Augmentin® (AMC) discs for estimating the susceptibility of bacteria to Clavamox Tablets and antibiotic drops.
Clavamox antibiotic for pets are indicated in the treatment of:
Skin infection in dogs and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., and E. coli. Periodontal or dental infection in dogs due to susceptible strains of both aerobic and anaerobic bacteria. Clavamox has been shown to be clinically effective for treating cases of canine periodontal disease.
Skin infection in cats and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., E. coli, Pasteurella multocida, and Pasteurella spp.
Urinary tract infections (cystitis) due to susceptible strains of E. coli.
Therapy may be initiated with Clavamox prior to obtaining results from bacteriological and susceptibility studies. A culture should be obtained prior to treatment to determine susceptibility of the organisms to Clavamox. Following determination of susceptibility results and clinical response to medication, therapy may be revaluated.
The use of this pet antibiotic medication is contraindicated in animals with a history of an allergic reaction to any of the penicillin or cephalosporins.
Clavamox contains semisynthetic penicillin (amoxicillin) and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids.
Safety of use of this antibiotic for pets in pregnant or breeding animals has not been determined. For use in dogs and cats only.
DOSAGE AND ADMINISTRATION:
The recommended dosage is 6.25 mg/lb (1 mL/10 lb) of body weight twice a day. Skin infection in dogs and soft tissue infections such as abscesses, cellulitis, wounds, superficial/juvenile pyoderma, and periodontal infections should be treated for 5-7 days or for 48 hours after all symptoms have subsided. If no response is seen after 5 days of this antibiotic for dogs, therapy should be discontinued and the case revaluated. Deep pyoderma may require treatment for 21 days; the maximum duration of dog medicine should not exceed 30 days.
The recommended dosage is 62.5 mg (1 mL) twice a day. Skin infection in cats and soft tissue infections such as abscesses and cellulitis/dermatitis should be treated for 5-7 days or 48 hours after all symptoms have subsided, not to exceed 30 days. If no response is seen after 3 days of antibiotic for cats treatment, therapy should be discontinued and the case revaluated.
Urinary tract infections may require treatment for 10-14 days or longer. The maximum duration of this antibiotic for pets should not exceed 30 days.
RECONSTITUTION INSTRUCTIONS–ORAL SUSPENSION:
Add 14 mL of water to the 15-mL bottle and shake vigorously. Each mL of suspension will contain 50 mg of amoxicillin activity as the trihydrate and 12.5 mg of clavulanic acid activity as the potassium salt.
Any unused portion of the reconstituted suspension must be discarded after 10 days. Refrigeration of the reconstituted suspension is required.
Clavamox antibiotic for pets are supplied in 15-mL bottles containing 50 mg of amoxicillin/12.5 mg of clavulanic acid per mL.
Clavamox and Augmentin are trademarks owned by and used under license from SmithKline Beecham.
Manufactured by: SmithKline Beecham Pharmaceuticals, Philadelphia, PA 19101