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Anipryl (Rx)

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Product Description

Anipryl 15 mg, 30 Tablets is the first FDA-approved monoamine oxidase inhibitor (MAOI) used to treat Canine Cognitive Dysfunction Syndrome. Many times, results come in as little as one month for dogs with Cushing’s Disease treated with Anipryl.

Anipryl tablets for dogs are white, convex tablets containing 2, 5, 10, 15, and 30 mg of selegiline HCl. It is commonly referred to in the clinical and pharmacological literature as L-deprenyl (the levorotatory form of deprenyl HCl). This medication is manufactured by Pfizer Animal Health.

You can order this FDA-approved medication for pets as well as other dog medicines and other pet prescription medication at our pet pharmacy online. Based in Houston, our online drug store understands the importance of pet in your life and offers the best services in pet medications.



  • First FDA approved medication to treat senility in dogs
  • Results in little as one month
  • Easy, once-daily oral dosing


Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Anipryl tablets for dogs are indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine pituitary dependent hyperadrenocorticism (PDH).

Anipryl is contraindicated in patients with known hypersensitivity to this drug. In humans, selegiline is contraindicated for use with meperidine and this contraindication is often extended to other opioids.

Keep out of reach of children. Not for human use. This dog medication should not be administered at doses exceeding those recommended (0.5-2.0 mg/kg once daily). In humans, concurrent use of MAO inhibitors with alpha-2 agonists has resulted in extreme fluctuations of blood pressure; therefore, blood pressure monitoring is recommended with concurrent use in dogs. Also, in humans, severe CNS toxicity including death has been reported with the combination of selegiline and tricyclic antidepressants, and selegiline and selective serotonin reuptake inhibitors. Although no such adverse drug interactions were reported in the clinical trials in dogs, it seems prudent to avoid the combination of Anipryl tablets for dogs and selective serotonin reuptake inhibitors (e.g., fluoxetine) as well as Anipryl and tricyclic (e.g., clomipramine, amitriptyline, imipramine) or other antidepressants.

At least 14 days should elapse between discontinuation of Anipryl and initiation of treatment with a tricyclic antidepressant or selective serotonin reuptake inhibitor. Because of the long half-life of fluoxetine and its active metabolites, at least 5 weeks should elapse between discontinuation of fluoxetine and initiation of treatment with Anipryl.

Concurrent use of Anipryl dog medication with ephedrine or potential MAO inhibitors, such as amitraz, is not recommended.

General: Anipryl is not recommended for other behavior problems in dogs such as aggression. In the clinical trials, 3 dogs showed an increase in aggression while on this drug. The safety and efficacy of Anipryl has not been evaluated in dogs with debilitating systemic diseases other than PDH.

The decision to prescribe Anipryl should take into consideration that the MAO system of enzymes is complex and incompletely understood and there is only a limited amount of carefully documented clinical experience with selegiline. Consequently, the full spectrum of possible responses to selegiline may not have been observed in pre-marketing evaluation of the drug.

It is advisable, therefore, to observe patients carefully for atypical responses. Endocrine function testing to confirm pituitary dependent hyperadrenocorticism should be performed prior to Anipryl administration for that condition. Anipryl is not recommended for treatment of patients with hyperadrenocorticism not of pituitary origin such as those due to an adrenal tumor or administration of glucocorticoids. If complications of PDH are evident at the time of diagnosis or emerge during Anipryl dog meds therapy, the patient should be evaluated and, if warranted, alternative therapy considered. Concurrent use of Anipryl in conjunction with other therapies of canine pituitary dependent hyperadrenocorticism has not been reported.

Laboratory Tests:
No specific laboratory tests are deemed essential for the management of patients on Anipryl dog meds as response to therapy should be based on the history and physical examinations for both PDH and CDS. In clinical trials for PDH, no correlation was found between an individual patient’s clinical response and results of the low dose dexamethasone suppression (LDDS) test. There was no evidence of adrenal insufficiency in these trials.

In the 12 week clinical trial for CDS, a small number of dogs had a drop in hematocrit; some dropping within the normal range and some dropping below 37%. The clinical significance of this is unknown at this time. It is advisable to conduct a thorough physical examination and to consider appropriate laboratory tests to establish hematological and serum biochemical baseline data prior to administration of Anipryl.

Reproductive Safety:
The safety of this dog medication in breeding, pregnant and lactating bitches and breeding dogs has not been determined.

In clinical trials, 404 dogs treated with Anipryl dog medication for as long as 18 months were monitored for the occurrence of adverse events. Many of the observations listed in the following table may be associated with the underlying disease (PDH or CDS), the advanced age of the patients or the development of unrelated concurrent disease. One index of relative importance, however is whether or not a reaction caused treatment discontinuation.

Eighteen dogs (4%) experienced one or more of the following adverse events that led either to discontinuation of therapy with Anipryl, dismissal from the study, or a reduction in dose: restlessness/agitation, vomiting, disorientation, diarrhea, diminished hearing, possible drug interaction (weakness, confusion, incoordination and “seizure-like” activity while being treated concurrently with metronidazole, prednisone, and trimethoprim sulfa), increase in destructive behavior in a dog with separation anxiety, anorexia, anemia, stiffness and polydipsia.

Percentage of Dogs with Adverse Events

Reported in Clinical Field Trials

Adverse EventAnipryl (n=404)Placebo (n=67)
urinary tract infection4%1%
pale gums3%1%
weight loss3%0
diminished hearing2%0

*This includes hyperactivity, irritability, abnormal repetitive movements, anxiousness, and restlessness.

**This includes ataxia, incoordination, staggering, disorientation, decreased proprioception, and seizure.

***This includes heart murmurs, tachycardia, collapse, dyspnea, pleural effusion, and sneezing.


Cognitive Dysfunction Syndrome (CDS):
The recommended dosage for oral administration for the control of clinical signs associated in dogs with Cognitive Dysfunction Syndrome (CDS) is 0.5-1.0 mg/kg once daily, preferably administered in the morning. Initially, dogs should be dosed to the nearest whole tablet. Adjustments should then be made based on response and tolerance to the drug.

Pituitary Dependent Hyperadrenocorticism (PDH):
The recommended dosage for the control of clinical signs associated with canine Pituitary Dependent Hyperadrenocorticism (PDH) is 1.0 mg/kg once daily, preferably administered in the morning. If no improvement is observed after 2 months of therapy, dosage may be increased to a maximum of 2.0 mg/kg once daily.

If no improvement is seen after 1 month at the higher dose or if at any time clinical signs progress, the dog should be re-evaluated. In dogs whose clinical signs of Pituitary Dependent Hyperadrenocorticism progress despite Anipryl therapy in the absence of concurrent disease, alternative therapy should be considered.

Dogs should be monitored closely for possible adverse events associated with any increase in dose.

Clinical Use of Anipryl in Cognitive Dysfunction Syndrome in Dogs:
Cognitive Dysfunction Syndrome in dogs is an age-related deterioration of cognitive abilities characterized by behavioral changes not wholly attributable to a general medical condition such as neoplasia, infection, or organ failure. Canine Cognitive Dysfunction Syndrome is typified by multiple cognitive impairments which affect the dog’s function. In clinical trials, the observed behavioral changes associated with Cognitive Dysfunction Syndrome in dogs (older included: disorientation, decreased activity level, abnormal sleep/wake cycles, loss of housetraining, decreased or altered responsiveness to family members, and decreased or altered greeting behavior. In clinical trials, Anipryl was shown to be effective in controlling clinical signs associated with Dog Cognitive Dysfunction Syndrome. After 4 weeks of treatment, dogs treated with Anipryl showed significant improvement when compared to placebo-treated controls in sleeping patterns, housetraining, and activity level. Some dogs showed increased improvement up to 3 months, however, onset, duration and magnitude of response varied with individual dogs.

The diagnosis of Cognitive Dysfunction Syndrome in dogs is a diagnosis of exclusion, based on thorough behavioral and medical histories, in conjunction with appropriate diagnostic work-up and testing.

Periodic patient monitoring to evaluate the response and tolerance to the drug and for the presence of concurrent or new disease is recommended.

Clinical Use of Anipryl in Pituitary Dependent Hyperadrenocorticism:
Clinical signs of Pituitary Dependent Hyperadrenocorticism seen in clinical trials included panting, reduced activity, polydipsia, polyuria, changes in sleep patterns, altered appetite, obesity, alopecia, abdominal distention, reduced skin elasticity, thin skin, poor hair growth, pyoderma, decreased responsiveness to attention, and decreased enthusiasm of greeting. In clinical studies involving 125 evaluable cases of naturally occurring Pituitary Dependent Hyperadrenocorticism, Anipryl was shown to be effective in controlling clinical signs associated with the disease. On physical examination, abdominal distention was the parameter which most consistently improved following treatment with Anipryl. Based on owner assessments, activity level was the parameter most consistently evaluated as “improved”. Approximately 60% of the dogs were evaluated by the veterinarians and owners to be “slightly improved” to “improved” after 1 month of Anipryl therapy. By month 2, veterinarians reported that approximately 77% were “slightly improved” to “improved”. Approximately 20% of dogs did not respond to Anipryl and were deemed treatment failures. Those dogs that responded to Anipryl tended to do so within 1-2 months after treatment was initiated. Response to therapy varied between patients with some dogs showing improvement in all presenting clinical signs and others showing improvement in only 1-2 parameters. Duration of response was also variable, with some dogs continuing on Anipryl for over 1 year with good control of clinical signs and others showing an initial response to therapy only to be followed within several months by recurrence of clinical signs of Pituitary Dependent Hyperadrenocorticism. There was no correlation demonstrated between an individual dog’s clinical response to Anipryl and that dog’s low dose dexamethasone suppression test results, therefore, monitoring should be based on history and physical examination findings.

In a laboratory safety study, Anipryl dog medication was administered orally to healthy adult beagles once daily for 6 months at doses of 0, 1, 2, 3, or 6 mg/kg (0.5x, 1x, 1.5x and 3x the maximum recommended daily dose of 2.0 mg/kg). The drug was demonstrated to be safe at the recommended dose range of 0.5-2.0 mg/kg. The following statistically significant clinical observations were noted in dogs in the 1.5x and 3x group: salivation, decreased pupillary response, and decreased body weight despite normal to increased feed consumption. Additional reactions seen at the 3x dose included panting, decreased skin elasticity (dehydration) and stereotypic behaviors, i.e., weaving (repetitive left to right movement) in the cage. This repetitive movement started several hours after dosing but was no longer present at the time of the next morning dose. There were no changes noted in blood pressure, heart rate and ECG parameters, nor were there any ophthalmic changes.

These prescription drugs for pets are available in five tablet strengths in blister-packs of 30 tablets for dogs each: 2 mg, 5 mg, 10 mg, 15 mg, and 30 mg. Each box contains 1 blister pack (30 tablets).

Store this dog medication at controlled room temperature 20°-25°C (68°-77°F).

Manufactured by: DRAXIS Specialty Pharmaceuticals Inc., Kirkland, QC, Canada H9H 4J4

Distributed by: Pfizer Animal Health, Div. of Pfizer Inc, NY, NY 10017

Additional Information

Bottle Size

15mg – 30 Tablet Pack, 30mg – 30 Tablet Pack

Product Type

Nutrition Medicine, OTC Medicine, Rx Medicine


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