Adequan Canine 5 mL Vial, Box of 2 Vials remedies symptoms of non-infectious degenerative and traumatic arthritis in dogs to reduce pain and increase mobility in dog. Adequan canine pain relief medicine helps increase the amount of synovial fluid in joints. Synovial fluid is a viscous liquid that cushions joints and protects them from friction.
Brand of Polysulfated Glycosaminoglycan Solution 100 mg/mL in a 5 mL preserved multiple dose vials for intramuscular use in arthritic dogs. This dog medicine is marketed by NOVARTIS ANIMAL HEALTH.
You can order the Adequan Canine and other dog medication for pain from our pet pharmacy online shop. At our Texas based pet drugs online shop, we offer quality dog medicines and other pet medications.
- Controls symptoms associated with arthritis in dogs
- Reduces joint pain in dogs as well as inflammation in dogs
- Supports regrowth of cartilage in arthritic dogs
- Enhances your dog’s quality of life
Caution: Federal law restricts this pet meds to use by or on the order of a licensed veterinarian.
The active ingredient in Adequan® Canine is Polysulfated glycosaminoglycan (PSGAG).
Polysulfated glycosaminoglycan is a semi-synthetic glycosaminoglycan prepared by extracting glycosaminoglycans (GAGs) from bovine tracheal cartilage. GAGs are polysaccharides composed of repeating disaccharide units. The GAG present in PSGAG is principally chondroitin sulfate containing 3 to 4 sulfate esters per disaccharide unit. The molecular weight for PSGAG used in the manufacture of Adequan® is 3,000 to 15,000 daltons. Each mL of Adequan Canine contains 100 mg of PSGAG, 0.9% v/v benzyl alcohol as a preservative, and water for injection q.s. to 1 mL. Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH.
The specific mechanism of action of Adequan pet meds in canine joints is not known. PSGAG is characterized as a “disease modifying osteoarthritis drug.”
Experiments conducted in vitro have shown PSGAG to inhibit certain catabolic enzymes which have increased activity in inflamed joints, and to enhance the activity of some anabolic enzymes. For example, PSGAG has been shown to significantly inhibit serine proteinases.
Serine proteinases have been demonstrated to play a role in the Interleukin-1 mediated degradation of cartilage proteoglycans and collagen. PSGAG is reported to be an inhibitor of Prostaglandin E2 (PGE2) synthesis. PGE2 has been shown to increase the loss of proteoglycan from cartilage. PSGAG has been reported to inhibit some catabolic enzymes such as elastase, stromelysin, metalloproteases, cathepsin B1, and hyaluronidases, which degrade collagen, proteoglycans, and hyaluronic acid in degenerative joint disease like arthritis in dogs.
Anabolic effects studied include ability to stimulate the synthesis of protein, collagen, proteoglycans, and hyaluronic acid in various cells and tissues in vitro. Cultured human and rabbit chondrocytes have shown increased synthesis of proteoglycan and hyaluronic acid in the presence of PSGAG. PSGAGs have shown a specific potentiating effect on hyaluronic acid synthesis by synovial membrane cells in vitro.
Absorption, distribution, metabolism, and excretion of PSGAG following intramuscular injection have been studied in several species, including rats, rabbits, humans, horses and dogs. Studies in rabbits showed maximum blood concentrations of PSGAG following IM injection were reached between 20 to 40 minutes following injection, and that the drug was distributed to all tissues studied, including articular cartilage, synovial fluid, adrenals, thyroid, peritoneal fluid, lungs, eyes, spinal cord, kidneys, brain, liver, spleen, bone marrow, skin, and heart.
Following intramuscular injection of PSGAG in humans, the pet meds was found to be bound to serum proteins.
PSGAG binds to both albumin and chi- and beta-globulins and the extent of the binding is suggested to be 30 to 40%. Therefore, the drug may be present in both bound and free form in the bloodstream. Because of its relatively low molecular weight, the synovial membrane is not a significant barrier to distribution of PSGAG from the bloodstream to the synovial fluid. Distribution from the synovial fluid to the cartilage takes place by diffusion. In the articular cartilage the drug is deposited into the cartilage matrix.
Serum and synovial fluid distribution curves of PSGAG have been studied in dogs and appear similar to those found in humans and rabbits.
In rabbits, metabolism of PSGAG is reported to take place in the liver, spleen, and bone marrow. Metabolism may also occur in the kidneys. PSGAG administered intramuscularly and not protein bound or bound to other tissues is excreted primarily via the kidneys, with a small proportion excreted in the feces.
In a sub acute toxicity study, 32 adult beagle dogs (4 males and 4 females per treatment group) received either 0.9% saline solution or PSGAG at a dose of 5 mg, 15 mg, or 50 mg per kg of body weight (approximately 2.3, 6.8, or 22.7 mg/lb), via intramuscular injection twice weekly for 13 weeks. PSGAG doses represent approximately 1X, 3X, and 10X the recommended dosage of 2 mg/lb, and more than 3 times the recommended 4-week duration of treatment. Necropsies were performed 24 hours after the final treatment.
During week 12, one dog in the 50 mg/kg dosage group developed a large hematoma at the injection site which necessitated euthanasia. No other mortalities occurred during the treatment period with this dog medication. Statistically significant changes in the 50 mg/kg group included increased prothrombin time, reduced platelet count, an increase in ALT and cholesterol, and increased liver and kidney weights. Increased cholesterol and kidney weights were also noted in the 15 mg/kg group. Microscopic lesions were noted in the liver (Kupffer cells containing eosinophilic foamy cytoplasm), kidneys (swollen, foamy cells in the proximal convoluted tubules), and lymph nodes (macrophages with eosinophilic foamy cytoplasm) in the 15 mg/kg and 50 mg/kg groups. Intramuscular inflammation, hemorrhage, and degeneration were seen in all 3 PSGAG treated groups; the incidence and severity appeared dose related.
Efficacy of Adequan Canine for dogs was demonstrated in two studies. A laboratory study using radiolabelled PSGAG established distribution of PSGAG into canine serum and synovial fluid following a single intramuscular injection of 2 mg/lb. A clinical field trial was conducted in dogs diagnosed with radio graphically-confirmed traumatic and/or degenerative joint disease of 1 or 2 joints. Joints evaluated included hips, stifles, shoulders, hocks and elbows. Fifty-one dogs were randomly assigned to receive either Adequan Canine at 2 mg/lb of body weight or 0.9% saline. Both treatments were administered by intramuscular injection twice weekly for 4 weeks (8 injections total). Investigators administering treatment and evaluating the dogs were unaware of the treatment assignment. A total of 71 limbs in 51 dogs were evaluated. Of these, 35 limbs in 24 dogs were in the Adequan Canine treated group. Each lame limb was scored for lameness at a walk, lameness at a trot, pain, range of motion, and functional disability. The scores for the individual parameters were combined to determine a total orthopedic score. At the end of the treatment period, arthritic dogs treated with Adequan Canine showed a statistically significant improvement in range of motion and total orthopedic score over placebo treated control dogs.
Indications and Usage:
Adequan Canine arthritis meds for dogs is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.
Do not use dog medication for pain in dogs showing hypersensitivity to PSGAG. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.
Studies to establish the safety of Adequan Canine in breeding, pregnant, or lactating dogs have not been conducted.
Use this pet meds with caution in dogs with renal or hepatic impairment.
In the clinical efficacy trial, 24 dogs were treated with Adequan Canine twice weekly for 4 weeks. Possible adverse reactions were reported after 2.1% of the injections. These included transient pain at the injection site (1 incident), transient diarrhea (1 incident each in 2 dogs), and abnormal bleeding (1 incident).
These effects were mild and self-limiting and did not require interruption of therapy.
Keep this and all pet medications out of the reach of children.
Dosage and Administration:
The recommended dose of Adequan Canine for dogs is 2 mg/lb body weight (.02 mL/lb, or 1 mL per 50 lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections).
Do not exceed the recommended dose or therapeutic regimen of this pet medicine. Do not mix Adequan Canine with other drugs or solvents.
Store this arthritis meds for dogs at controlled room temperature up to 25°C (77°F) (See USP).
NOVARTIS Adequan Canine Solution 100 mg/mL in a 5 mL preserved multiple dose vial.
|Product ID # 97502||5 mL Multiple Dose Vials||Packaged 2 vials per box|
LUITPOLD PHARMACEUTICALS, INC., Animal Health Division, Shirley, NY 11967
(631) 924-4000 1-800-458-0163
NOVARTIS ANIMAL HEALTH US, INC., Greensboro, NC 27408